Our compadres south of the border boast a unique and flavorful cuisine steeped in history and bursting with native ingredients dating back to the Aztecs. The basic and fully adjusted models produced approximately the same estimates, except for the similar increases by adjustments in HR for the groups intending to lose weight and actually losing weight or maintaining it. The HR for mortality following intended weight loss increased from 1.49 to 1.87 and became statistically significant (p decreased from 0.06 to 0.004) with the adjustments of the fully adjusted model. In stepwise rebuilding of the model, it was found that adjustment for smoking increased the HR from 1.49 to 1.66, and further adjustment for physical activity increased the HR from 1.66 to 1.85, indicating the importance of these two variables as confounders; the group with intent to lose weight and actual weight loss smoked less and exercised more than other groups.
It would also be a mistake to reject a drug that works well for a subset of the patient population, says Thomas. About 20% of people on the drug lost 10% or more of their body weight. The FDA recommends that patients who have not lost 5% of body weight by week 12 stop taking the drug.
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